Data di Pubblicazione:
2003
Citazione:
Effect of loperamide on gastro-oesophageal reflux / M. Allocca, M. Mangano, P. Colombo, R. Penagini. - In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0036-5521. - 38:4(2003), pp. 343-346.
Abstract:
Background: We have recently shown that morphine reduces gastro-oesophageal reflux (GOR) by stimulating opioid receptors. Our aim was therefore to investigate the effect of loperamide, a peripheral opioid agonist, on GOR. Methods: Nine patients with GOR disease underwent two ambulatory 24-h intra-oesophageal pH monitoring sessions separated by a period of at least 7 days under double-blind randomized conditions during the administration of placebo or loperamide solution p.o. (8 mg + 4 mg + 4 mg, 12 h and 2 h before, and 7 h after the start of the recording). Results: Twenty-four-hour oesophageal acid exposure and the number of reflux episodes/hour were similar under the two experimental conditions: a median (IQ range) of 6.2% (3.3%-11.0%) of the time at pH <4 and 2.6 (1.6-3.5)/h during placebo versus 8.8% (3.7%-14.8%) and 2.8 (2.3-4.9)/h during loperamide (P= ns). Acid clearance time was also similar: 1.8±0.3 min versus 1.6±0.2 min (P=ns). Conclusions: Loperamide did not decrease GOR, thus suggesting that an opioid agonist may not be useful in the treatment of GOR disease.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Allocca, M. Mangano, P. Colombo, R. Penagini
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