Reduced intensity stem cell transplantation for advanced soft tissue sarcomas in adults : a retrospective analysis of the European Group for Blood and Marrow Transplantation
Articolo
Data di Pubblicazione:
2007
Citazione:
Reduced intensity stem cell transplantation for advanced soft tissue sarcomas in adults : a retrospective analysis of the European Group for Blood and Marrow Transplantation / S. Secondino, M.G. Carrabba, P. Pedrazzoli, L. Castagna, F. Spina, F. Grosso, A. Bertuzzi, J.O. Bay, S. Siena, P. Corradini, D. Niederwieser, T. Demirer, European Group for Blood and Marrow Transplantation Solid Tumors Working Party. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 92:3(2007 Mar 01), pp. 418-420. [10.3324/haematol.10521]
Abstract:
We conducted a retrospective analysis on adult patients with advanced soft tissue sarcoma (STS) other than rhabdomyosarcoma who received allogeneic stem cell transplantation and were registered at the EBMT database. The aim of of the study was to assess whether an immune-mediated graft-versus-tumor (GVT) effect could be generated in this disease. Among 26 patients included in the registry, 14 were eligible for this analysis as they had received reduced intensity stem cell transplantation for chemorefractory disease. Two patients died of transplant-related complications and eight of progressive disease; four are alive and experienced long-lasting disease stabilisation following transplant. Our study may suggest that an immune-mediated effect cannot be excluded in some STS.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
non-myeloablative ; allogeneic SCT ; soft tissue sarcoma ; graft-versus-tumor
Elenco autori:
S. Secondino, M.G. Carrabba, P. Pedrazzoli, L. Castagna, F. Spina, F. Grosso, A. Bertuzzi, J.O. Bay, S. Siena, P. Corradini, D. Niederwieser, T. Demirer, European Group for Blood, Marrow Transplantation Solid Tumors Working Party
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