Olanzapine, but not haloperidol, enhances PSA-NCAM immunoreactivity in rat prefrontal cortex
Articolo
Data di Pubblicazione:
2008
Citazione:
Olanzapine, but not haloperidol, enhances PSA-NCAM immunoreactivity in rat prefrontal cortex / A. Frasca, F. Fumagalli, J. Ter Horst, G. Racagni, K.J. Murphy, M.A. Riva. - In: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. - ISSN 1461-1457. - 11:5(2008 Aug), pp. 591-595. [10.1017/S1461145708009061]
Abstract:
Repeated antipsychotic treatment may produce adaptive changes ranging from cytoarchitectural rearrangements to synaptic modifications that might contribute to clinical improvement. We performed a prolonged treatment (2 wk) with the first-generation antipsychotic (FGA) haloperidol (1 mg/kg) and the second-generation antipsychotic (SGA) olanzapine (2 mg/kg twice daily) and analysed the expression of the polysialylated form of neural cell adhesion molecule (PSA-NCAM) in rat hippocampus and prefrontal cortex via immunohistochemistry. We found a regional- and drug-selective increase of PSA-NCAM expression in prefrontal cortex of olanzapine-treated rats with no effects in hippocampus; conversely, haloperidol did not produce a change in either brain region. Our findings reveal a possible role for PSA-NCAM in the mechanism of action of the SGA olanzapine adding complexity as well as specificity to the molecular changes set in motion by this drug
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Frasca, F. Fumagalli, J. Ter Horst, G. Racagni, K.J. Murphy, M.A. Riva
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