Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum
Articolo
Data di Pubblicazione:
2008
Citazione:
Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum / F. Gardoni, A. Frasca, E. Zianni, M.A. Riva, M. Di Luca, F. Fumagalli. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 18:7(2008 Jul), pp. 531-534.
Abstract:
We here show that repeated administration of the first generation antipsychotic haloperidol, but not of the second generation olanzapine, significantly reduced the expression of NMDA subunit NR2A at striatal synapses, whereas both drugs decreased alpha CaMKII protein levels and autophosphorylation degree. Given that alterations in the localization of NMDA receptor regulatory subunits at synapses have been described in experimental parkinsonism, the haloperidol-induced effect on NMDA subunit localization might contribute to drug-induced parkinsonism induced by haloperidol
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
postsynaptic density ; striatum ; CaMKII ; antipsychotic ; NMDA receptor ; rat
Elenco autori:
F. Gardoni, A. Frasca, E. Zianni, M.A. Riva, M. Di Luca, F. Fumagalli
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