Data di Pubblicazione:
2004
Citazione:
Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs' / S. Romeo, M. Dell'Agli, S. Parapini, L. Rizzi, G. Galli, M. Mondani, A.C. Sparatore, D. Taramelli, E.A. Bosisio. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 14:11(2004), pp. 2931-2934.
Abstract:
Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the ‘double-drug' approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 μM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chimera drug; Double drug; In vitro inhibition; P. falciparum; Plasmepsin II; Primaquine; Statine
Elenco autori:
S. Romeo, M. Dell'Agli, S. Parapini, L. Rizzi, G. Galli, M. Mondani, A.C. Sparatore, D. Taramelli, E.A. Bosisio
Link alla scheda completa: