Data di Pubblicazione:
2008
Citazione:
MDC/CCL22 intrathecal levels in patients with multiple sclerosis / D. Galimberti, C. Fenoglio, C. Comi, D. Scalabrini, M.A. De Riz, M. Leone, E. Venturelli, F. Cortini, M. Piola, F. Monaco, N. Bresolin, E.A. Scarpini. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 14:4(2008 May), pp. 547-549. [10.1177/1352458507084268]
Abstract:
MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple
sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying
patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cerebrospinal fluid; MDC/CCL22; Multiple sclerosis
Elenco autori:
D. Galimberti, C. Fenoglio, C. Comi, D. Scalabrini, M.A. De Riz, M. Leone, E. Venturelli, F. Cortini, M. Piola, F. Monaco, N. Bresolin, E.A. Scarpini
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