Self-collected urine sampling to study the kinetics of urinary toluene (and o-cresol) and define the best sampling time for biomonitoring
Articolo
Data di Pubblicazione:
2009
Citazione:
Self-collected urine sampling to study the kinetics of urinary toluene (and o-cresol) and define the best sampling time for biomonitoring / S. Fustinoni, R. Mercadante, L. Campo. - In: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. - ISSN 0340-0131. - 82:6(2009), pp. 703-713.
Abstract:
Purpose To study the excretion kinetics of urinary toluene,
TOL-U, and o-cresol, o-C, following occupational
exposure to toluene in order to define the best time for
sample collection, to apply a non-invasive approach based
on self-collected urine sampling.
Methods Five rotogravure printing workers exposed to
uncontrolled levels of toluene collected spot urine samples
over three consecutive working days and the following day
of rest. In each sample TOL-U and o-C were measured and
kinetics of excretion evaluated.
Results Toluene exposure ranged from 48.3 to 75.3 mg/
m3; TOL-U and o-C ranged from 1.4 to 34.6 lg/L and from
0.013 to 1.012 mg/L. A time course trend was obtained:
TOL-U and o-C increased during the shift and peaked at
the end of exposure and up to 2 h later, respectively;
afterwards they rapidly decreased following apparent first
order kinetics. Considering TOL-U, the elimination halflife
for the first fast phase was 79 (±35 standard error) min,
and for the second slow phase was 1,320 (±1,162) min. For
o-C the elimination half-life for the first fast phase was 231
(±48) min. Considering a toluene uptake of 86%, TOL-U
and o-C excreted in urine were about 0.0067 and 0.18% of
the up taken.
Conclusion Our results support the use of end shift TOLU
as a short term biomarker of occupational exposure to
toluene and show the feasibility of self-collected urine
sampling to investigate the elimination kinetics of industrial
toxics in humans.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biological monitoring; Kinetics of elimination; o-Cresol; Occupational exposure; Self-monitoring; Toluene
Elenco autori:
S. Fustinoni, R. Mercadante, L. Campo
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