Data di Pubblicazione:
2008
Citazione:
The feline acute phase reaction / S. Paltrinieri. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 177:1(2008 Jul), pp. 26-35. [10.1016/j.tvjl.2007.06.005]
Abstract:
The acute phase reaction (APR) is a response to potentially pathogenic stimuli. It begins with the release of interleukin (IL)-1, IL-6
and tumour necrosis factor (TNF)-a from inflammatory cells. These cytokines induce fever, leucocytosis and release of serum acute phase proteins (APPs). In this review, the characteristics of the feline APR are described. In cats with inflammatory conditions, fever is a common finding, with leucocytosis due to the release of cells from the marginal pool, followed by activation of myelopoiesis. Because
excitement frequently causes leucocytosis in cats, a diagnosis of inflammation should therefore be supported by additional findings such as the presence of toxic neutrophils. The major APPs are serum amyloid A and a1-acid glycoprotein (AGP), which both increase a few hours after the inflammatory stimulus and remain elevated for as long as the inflammation persists. AGP plays an important role in the
diagnosis of feline infectious peritonitis (FIP) and may also be useful also in studies of FIP pathogenesis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acute phase proteins; Acute phase reaction; Feline; Fever; Leucocytosis
Elenco autori:
S. Paltrinieri
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